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The first line of defense for dental pain has always been anti-inflammatory medications like acetaminophen (Tylenol), ibuprofen (Advil, Motrin) or naproxen (Aleve), but many patients cant take such medications or cant get sufficient relief from them, so dentists have traditionally been among the largest prescribers of opioid medications, either alone or in combination with these other medications, said lead study author Vanessa Chrepa, an associate professor at the Rutgers School of Dental Medicine and director of clinical and translational research at the schools Department of Endodontics